


Sir Ronald Aylmer Fisher was a British geneticist and statistician. To create genetic experiments that yielded greater results with less effort, he pioneered the use of statistics in experimentation, and came up with the now widely used concepts of variance and randomization. Fisher wrote about 300 papers and seven books during his prodigious career.
The youngest of seven children, Ronald Fisher was born on February 17, 1890, in a northern suburb of London. Because of poor eyesight, the young Fisher was not allowed to read or write under artificial light. Consequently, he rarely took notes at lectures he attended, and he preferred to solve problems mentally rather than on paper. He developed a facility for visualizing complex geometrical relationships in his mind. This ability later proved fruitful, as his geometrical interpretation of statistics led him to previously unattainable results.
In 1909, Fisher earned a scholarship to attend Gonville and Caius College in Cambridge, where he specialized in mathematics and theoretical physics while also studying genetics. Fisher graduated from the University of Cambridge with a B.A. in astronomy in 1912. While there, he gained an interest in the theory of errors in astronomical observations, which eventually led him to a career in statistical research. For the next six years, Fisher searched for the right type of occupation, even working briefly as a farm laborer in Canada. Primarily, however, he worked as a statistician for the Mercantile and General Investment Company in London (1913 to 1915) and as a public school teacher (1915 to 1919). He was unhappy and, apparently, ineffective as a teacher–throughout his career, he was recognized as a brilliant thinker who had difficulty explaining his ideas to others. In 1917, he married Ruth Eileen Guinness; they had eight children and eventually separated.
Even though his jobs did not support research, Fisher published several papers during this period. He wrote two papers on eugenics (the science of improving the human race through selective mating); his concern that the less talented lower classes produced offspring at a faster rate than the more capable upper classes influenced his personal choice to have a large family.
In 1919, he accepted a position as statistician for the Rothamsted Agricultural Experimental Station near Harpenden, Hertfordshire. His work on plant-breeding experiments combined biology and statistics. At Rothamsted, he developed a new technique by which scientists could vary different elements in an experiment to determine the probability that those variations would yield different results. He published his findings in the book Statistical Methods for Research Workers (1925).
While at Rothamsted, Fisher also introduced new theories about randomization and variance, included in his work The Genetical Theory of Natural Selection (1930), which are now widely used in the field of genetics. His goal was to design plant-breeding experiments to yield the maximum results while using the least amount of time, effort, and money. One problem he discovered was biased selection of materials, which could lead to inaccurate results. To avoid this, Fisher introduced the concept of randomization, which provided that experiments must be conducted among a random sample of the entire population, and must be repeated on a number of control subjects to ensure validity.
Fisher also introduced his concept of variance. At the time, scientists were only able to vary one factor at a time in experiments, allowing for only one potential result. He proposed instead a statistical procedure by which experiments would be designed to answer several questions at once. This was accomplished by dividing each experiment into a series of sub-experiments, each of which differed enough to provide several unique outcomes. Fisher summed up his statistical work in his definitive work, Statistical Methods and Scientific Inference (1956).
Fisher was knighted in 1952. His last years were spent conducting research in Australia, where he died on July 29, 1962.














































